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          Preclinical Magnetic Particle Imaging (MPI) scanner

          Three-dimensional images at millisecond intervals, providing the potential for real-time 3D imaging in vivo

          MPI is a tomographic imaging technique that detects the magnetic properties of iron-oxide nanoparticles injected into the bloodstream to produce threedimensional images. The new technology, invented by Philips, and first introduced in a 2005 Nature paper, gave rise to a high aspirations for a new era in biological imaging.

          Now Bruker has combined its expertise in technological innovation with its passion for pushing the boundaries of understanding, and launched the previously only envisioned possibilities to the imaging community.

          1,000 Times Faster Than PET
          With MPI, imaging of up to 46 volumes per second can be performed, allowing real time imaging of biological processes at an equal or higher spatial resolution than with PET.

          100% Animal Visualization
          MPI measures the 3D distribution of injected iron oxide nanoparticles using a 25 kHz RF signal. This signal can easily be recorded from any depth within the animal allowing complete flexiblity in choosing areas of interest.

          100% User-Friendly
          Bruker’s MPI System incorporates ParaVision? 6 and accommodates Bruker‘s multi-modal bed, providing a seamless transition of your animal to and from your
          Bruker MRI system.

          Unimagined Temporal Resolution
          The ability to acquire high time-resolution images in a matter of milliseconds allows for novel applications in medical and industrial research and ultimately patient
          care in which temporal resolution is key.

          • Up to 46 volumes/sec
          • Full 1D…3D+t capability
          • 7 channel electromagnet
          • 3 orthogonal TxRx channels
          • 1D RX only coil inserts (optional)
          • Wide bore imager
          • Large FoV reconstruction
          • A VANCE III(HD) electronic
          • Fully flexible sequence design
          • Open method design
          • Access to all raw data
          • One click data acquisition and reconstruction
          • Spatially selectivity via FFP
          • In situ theranostic hyperthermia insert (upon request)

          Real time 3D Magnetic Particle Imaging (3D MPI) based on acquisition of 46 frames per second.

          Visit our MPI hub to watch informative videos, read scientific literature and learn more about the collaboration between Bruker and Philips.

          Applications

          Oncology

          Oncology AOncology B
          • Spatially selective tumor therapy
          • in situ hyperthermia therapy
          • Temperature monitoring
          • Tumor therapy assessment
          • Cancer staging

          Cardio Vascular

          Cardiovascular
          J. Franke, et al. "MPI Flow Analysis Toolbox exploiting pulsed tracer information an aneurysm phantom proof ." International Journal on Magnetic Particle Imaging 3.1 (2017)
          J. Franke, et al. "MPI based 4D flow estimation a simulation study." Proceedings IWMPI 2018
          • Stenosis staging
          • Plaque detection
          • Plaque staging
          • Real-time bolus tracking
          • Velocity reconstruction
          • Output fraction
          • Functional parameter

          Interventions

          Interventions
          Bakenecker , Anna C., et al. "Actuation and visualization of a magnetically coated swimmer with magnetic particle imaging." Journal of Magnetism and Magnetic Materials 473 (2019): 495 500.Device
          • actuation/steering
          • Spatially selective actuation
          • (Nano-)bot steering

          Neurology

          Neurology ANeurology B
          P. Ludewig , et al. "Magnetic Particle Imaging for Real Time Perfusion Imaging in Acute Stroke." ACS nano 11.10 (2017): 10480 10488.
          • fMPI, Neurodegeneration
          • Acute stroke detection
          • Local and reversible Blood
          • Brain Barrier opening
          • Direct brain cancer treatment
          • Drug delivery
          • Localized hyperthermia

          Theranostics

          Theranostics ATheranostics B
          C. Stehning et al., " Simultaneous MPI and temperature mapping using multi color MPI." International Journal on Magnetic Particle Imaging 2.2 (2016).
          • in situ diagnostic and therapy system
          • Morphology
          • Therapy planning and monitoring
          • Spatially selective therapy
          • Spatially selective hyperthermia
          • Thermometry

          Lung Diagnosis

          Lung Diagnosis
          Phys Med Biol. 2017 May 7;62(9):3510 3522. doi : 10.1088/1361 6560/aa616c. Epub 2017 Feb 20.
          •   
          • Perfusion
          • Ventilation

          Molecular Imaging

          Molecular Imaging
          H. Paysen , et al. Cellular uptake of magnetic nanoparticles imaged and quantified by magnetic particle imaging “. Scientific Reports, 10(1). https://doi.org/10.1038/s41598 020 58853 3
          • Stem cell tracking
          • Cell quantification
          • Cell viability
          • Functionalized tracer
          • Specific targeting
          • Cell-labeling
          • Inflammation

          Personalized Medicine

          Personalized medicine
          P. Szwargulski , et al.; Dynamic Multi Contrast Imaging of Two Different Tracer Materials in a Healthy Mouse IWMPI 2019
          • Pharmacokinetics
          • Targeted drug delivery
          • Spatially selective drug activation

          Gastro Intestinal

          Gastri Intestinal
          ACS Nano. 2017 Dec 26;11(12):12067 12076. doi : 10.1021/acsnano.7b04844. Epub 2017 Nov 30.
          •   
          • Gut bleeding
          • Ileus detection and staging

          Partnering in Innovation

          The result of an exclusive collaboration, the MPI system combines Bruker’s leading expertise in analytical magnetic resonance instruments and preclinical Magnetic Resonance Imaging (MRI) with Philips’ unique strengths in medical imaging.

          MPI is a completely new preclinical imaging technique with enormous potential to deliver new insights into disease processes at the organ, cellular and molecular level. With the new MPI system, Bruker further complements its extensive preclinical imaging product portfolio that includes MRI, PET, SPECT, micro-CT, optical molecular imaging and X-ray.

          Features

          • Powerful drive, selection, and focus field technologies ParaVision? acquisition and processing platform with DICOM export and import
          • Full 3D imaging and segmented acquisition capability
          • Bolus injection triggering via ParaVision?
          • Bruker’s multi-modality animal handling system
          • 12 cm free access for imaging of mice, rats, guinea pigs and rabbits
          • Bruker AVANCE? III / MPI technology
          • Recommended morphology reference: Desktop MRI ICON?
          MPI-signal.JPG
          Temporal evolution of the MPI signal within the field of view during a rat heart bolus injection measurement. The inflow of the contrast agentinto the field of view around the heart is seen approximately 2 seconds after the start of injection.
          The ParaVision 6 Interface for MPI Measurements
          4,000 repetitions in less than 90 seconds.

          MPI is a tomographic imaging technique that detects the magnetic properties of iron-oxide nanoparticles injected into the bloodstream to produce three-dimensional images MPI PreClinical Brochure

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